Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine.
نویسندگان
چکیده
Two novel SF5 analogs of the antimalarial agent mefloquine were synthesized in 5 steps and 10-23% overall yields and found to have improved activity and selectivity against malaria parasites. This work also represents the first report of SF5-substituted quinolines.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 7 20 شماره
صفحات -
تاریخ انتشار 2009